Activated ab2 Oncogenes and Apoptosis: Differing Responses of Transformed Myeloid Progenitor Cell Lines
نویسندگان
چکیده
Activation of the c-ablprotooncogene occurs during the generation of both the Abelson murine leukemia virus and the bcrablfusion gene. To further dissect the biological properties of these proteins, we studied their effect on apoptosis. Using dimethyl sulfoxide (DMSO) to induce apoptosis in the murine myeloid progenitor cell line 32Dc13, we examined the effect of expression of both v-ab1 and bcrabl transgenes on apoptosis. v-ab1 expressing 32Dc13 cells are sensitive to apoptosis induction, similar to parental 32Dc13 cells. In contrast, bcrabl expressing 32Dc13 cells are protected from the apoptotic stimulus resulting from DMSO exposure. Analyzing the expression patterns for Bcl-2 and Bax, two proteins
منابع مشابه
Activated abl oncogenes and apoptosis: differing responses of transformed myeloid progenitor cell lines.
Activation of the c-abl protooncogene occurs during the generation of both the Abelson murine leukemia virus and the bcrabl fusion gene. To further dissect the biological properties of these proteins, we studied their effect on apoptosis. Using dimethyl sulfoxide (DMSO) to induce apoptosis in the murine myeloid progenitor cell line 32Dcl3, we examined the effect of expression of both v-abl and ...
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